皇冠即时比分

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Ca泵浅析

水泵百科 卧泉泵业 663浏览 0评论

皇冠即时比分GAIBENG(calcium pump) YICHENGWEICa2+-ATPMEI,TACUIHUAZHIMONEICEDEATPSHUIJIE,SHIFANGCHUNENGLIANG,QUDONGXIBAONEIDEGAILIZIBENGCHUXIBAOHUOZHEBENGRUNEIZHIWANGQIANGZHONGCHUCUNQILAI,YIWEICHIXIBAONEIDINONGDUDEYOULICa+。YOUYUQIHUOXINGYILAIYUATPYUMg2+DEJIEHE,SUOYIYOUCHENGWEI(Ca2+,Mg2+)-ATPMEI。

1JIANJIE

GAILIZIBENG(CaBENGHUOCa2+BENG)

Ca2+-Mg2+-ATPMEI(JIGAIBENG)SHICUNZAIYUZUZHIXIBAOJIXIBAOQIDEMOSHANGDEYIZHONGDANBAIMEI,YOUYUQILIZIYUNZHUANSHIJIEZHULEISIBENGDEJIZHILAIWANCHENGDE,YIXUESHANGJIANGLIZIDEZHEIZHONGYUNZHUANFANGSHICHENGWEI”BENG”。TONGGUODUI”GAIBENG”DEYIWU

SHIYANJIU,YOUXIEXUEZHERENWEI,RENTIJIBINGHESHUAILAODEGUOCHENGJIUSHIYOUYUGEZHONGYUANYINSUOZHIJITI”GAIBENG”SHIDIAO,YINQIXIBAONEIGAILIZIHANLIANGZENGJIA、XIBAONEI、WAIGAILIZINONGDUCHAXIAJIANGERXINGCHENGDE。YOURENJIANGZHEIZHONGRENTINEIGAIKUAMOFENBUTIDUJIANGDIDEGUOCHENGCHENGZHIWEI”JITIHUANMANSIWANG”GUOCHENG。YOUCIKEJIAN,GAILIZIDEZHENGCHANGFENBUYEYURENTISHENGHUOHUODONGYOUZHEFEICHANGMIQIEDELIANXI。

XINGZHI:DIAOJIEGAIZAISHENGWUMOZHONGDEJIHUOZHUANYIDEJIEGOUHUOJIZHI。TASHIYOUCa2+-SANLINSUANXIANGANMEI(Ca2+-ATPase)ZAIMOSHANGZUZHUANGERCHENG。ZAIHONGXIBAOZHIMOSHANGDEGAIBENGBABAOZHIYOULICa2+SHUSONGDAOBAOWAI;ZAIJIHONGXIBAO,JIZHIWANGSHANGDEGAIBENGBACa2+CONGJIJIANGYUNSHUDAOJIZHIWANGNEI。

2JIEGOUYUGONGNENG

Ca2+BENGFENBUZAIDONG,ZHIWUXIBAOZHIMO,XIANLITINEIMO,NEIZHIWANGYANGNANGMO(SER-like organelle),DONGWUJIROUXIBAOJIZHIWANGMO,ZHIWUYELVTIMOSHANGSHANG,SHIYOU1000GEANJISUANDEDUOTAILIANXINGCHENGDEKUAMODANBAI,TASHICa2+JIHUODEATPMEI,MEISHUIJIEYIGEATPZHUANYUNLIANGGECa2+DAOXIBAONEI,XINGCHENGGAILIZITIDU.TONGCHANGXIBAOZHIYOULICa2+NONGDUHENDI,YUE10-7~10-8MOER/SHENG,XIBAOJIANYECa2+NONGDUJIAOGAO,YUE5×10-3MOER/SHENG.BAOWAIDECa2+JISHIHENSHAOLIANGYONGRUBAONEIDOUHUIYINQIBAOZHIYOULICa2+NONGDUXIANZHUBIANHUA,DAOZHIYIXILIESHENGLIFANYING.GAILIUNENGXUNSUDIJIANGXIBAOWAIXINHAOCHUANRUXIBAONEI,YINCICa2+SHIYIZHONGSHIFENZHONGYAODEXINHAOWUZHI.XIANLITINEIQIANG,JIZHIWANG,NEIZHIWANGYANGNANGQIANGZHONGHANGAONONGDUDECa2+,NONGDUDAYU10-5MOER/SHENG,MINGWEI”GAIKU”.ZAIYIDINGDEXINHAOZUOYONGXIACa2+CONGGAIKUSHIFANGDAOXIBAOZHI,DIAOJIEXIBAOYUNDONG,JIROUSHOUSUO,SHENGZHANG,FENHUADENGZHUDUOSHENGLIGONGNENG.

JIEGOU

皇冠即时比分CaLIZIDEJIEHEYUSHIYOU4GEα-LUOXUANZUCHENGDEKUAMOQU(DANBAIZHIBIANHAOleul).TUZHONGSUOZHANSHIDEJIUSHIYIGETONGDAOLUOXUAN(DANBAIZHIBIANHAO1eul)。LIANGGELANLVSEDEQIUBIAOSHIGAILIZI,TAMENBEIFUZESHOUJIDEANJISUANSUOGUDING。ZHEIXIEANJISUANJISHITUZHONGDEQIUHEGUN。ZHEILIANGGEGAILIZIKEYIXIEDIAOZHEIXIEDANBAIYAJIZAIGEGEFANGXIANGSHANGDEPINGHENG。RUOCaLIZIWEIZHIFASHENGGAIBIAN,ZEGAIDANBAIDEWENDINGXINGDADAJIANGDI.KECANKANWUCaLIZIZHUANGTAISHIDEGAIBENGJIEGOU(DANBAIZHIBIANHAOliwo)。LIRU:DANGJIARUYIZHONGKEJIEHEYUCaLIZIJIEHEWEIDIANLINJINQUYUCONGERSHIGAIDANBAICHUYUYIGEWENDINGDANSHIHUOZHUANGTAIDEYAOWUFENZISHI,GAIBENGJIUHUIHENKUAIBEIRONGJIE。

GONGNENG

(1)HONGXUEQIUDEXIBAONEIWAICa2+DENONGDUTIDUHENDA,KEYIRENWEIZHEISHIYOUCUNZAIYUMOSHANGDECa2+YILAIXINGATPMEISUOYINQIDECa2+DEZHUDONGPAICHU;

皇冠即时比分(2)JIJIANGWANGSHIKAOMOSHANGDEMg2+、 Ca2+ATPMEILAIJINXINGCa2+DEZHUDONGYUNSHUDE;

皇冠即时比分(3)XIANLITIMOYIKAODIANZICHUANDINENG,YI1∶1ZHIBISHEQUCa2+HELINSUAN;

皇冠即时比分(4)XIAOCHANGZHANMOSHANGPIXIBAOCONGSHIWUZHONGSHEQUCa2+,CISHIWEISHENGSUDSHIBIXUYINZI。SUOYOUZHEIXIEDOUKECHENGZUOGAIBENG,DANXIAYIDESHIZHI(1)HE(2),ER(4)SHIHENGGUANXIBAODEYUNSHU,QIYUDEDOUSHIMONEIWAIZHIJIANDEYUNSHU。

ZHUANYIGAILIZI

GAIBENGSHIYIGEHENQIGUAIDE”JIQI”,SHIYOUHAOJIGEKEYUNDONGBUFENZUCHENG。RUTUSUOSHI(DANBAIZHIBIANHAO1eul)TAYOUHENDAYIBUFENSHENCHUNEIZHIWANG,HAIYOUYIBUFENZAINEIZHIWANGMONEIQIGUDINGZUOYONG,ZHENGGEXINGZHUANGXIANGYIGEGUANCHUANMODETONGDAO。MEISHUIJIEYIGEATP,TAKEZHUANYUNLIANGGEGAILIZI(RUTULANSEBUFENSUOSHI)JINRUJIZHIWANG,TONGSHI,ZHUANYUNLIANGDAOSANGEQINGLIZILIKAIJIZHIWANG。DANGBENGCHUGAILIZISHI,GAIBENGFASHENGWANQUHESHOUSUO。

 

 

3GAIBENGXUNHUAN

ZAIGAILIZIZHUANYIDEGUOCHENGZHONG,GAIBENGFASHENGYIXILIEDEGOUXIANGBIANHUA。YIBANRENWEIJINGLISIGEBUZHOU,JIAOCHANGJIANDEGAIBENGGOUXIANGYOULIANGZHONG:ZUOTUDEJIEGOU(DANBAIZHIBIANHAOliwo)WEIKAIFANGZHUANGTAI,TUICEZAIQIZHUANYIWEIDIANYOUQINGLIZICUNZAI,JINGUANZAIQIJINGTIJIEGUOZHONGBINGWEIFAXIANQINGLIZI,DANDANGCHUYUKAIFANGXINGDEJIEGOUBIANWEISHANGMIANYOUTUSUOSHIDEJIEGOUSHI(DANBAIZHIBIANHAOleul),YUNXUGAILIZICONGBAOWAIJINRUQIANGNEI,BINGJIANGQINGLIZIBENGDAOBAOZHIZHONG。XIAMIANDELIANGBUTONGGUOYIGEATPFENZIGAIBIANGAIBENGDEGOUXIANGYILIYUGAILIZIDESHIFANG。ZAIGAIGUOCHENGZHONG,WEIYUANJISUANXULIE351WEIDETIANDONGANSUANLINSUANHUA(YONGHONGSEBIAOSHI),CONGSHANGTUKEYIKANCHU,GAITIANDONGANSUANYUTUICEDEATPJIEHEWEIDIAN(JIEJINTIANDONGANSUAN)WEIYUJUGAILIZIJIAOYUANDEWEIZHI。SHANGSHUGUOCHENGDEDIAOKONGSHITONGGUOATPJIEHEYUDEBIANHUASHITONGDAODANBAISHIDANGDECHENGKAIFANGHUOGUANBIZHUANGTAI,JINERKONGZHIGAILIZIDELIUDONG。

4SHOUSUOHESHUZHANG

皇冠即时比分ZHIYAOWOMENSHAOWEIYIDONG,JIUXUYAOSHUYIYIWANJIDEJIQIUDANBAIFADONGJI(YIZHONGDANBAIZHIFENZI)DEGONGZUO。WOMENDEJIROUXIBAOSHITONGGUOGAILIZILAIXIEDIAORUCIDALIANGDEFENZIGONGZUODE。DANGJIXIBAOSHOUDAOYUTAXIANGLIANDESHENJINGCHUANDIDEXINHAOHOU,TAJIUCONGJIZHIWANG(JIJIROUXIBAOZHONGDENEIZHIWANG,BEIDALIANGJIDONGDANBAIXIANWEIHEJIQIUDANBAIXIANWEIBAOWEI)ZHONGSHIFANGDALIANGDEGAILIZI。ZHEIXIEGAILIZIXUNSUDIKUOSANBINGQIEZHANFUDAOYUNDONGXIANWEISHANGDEYUANJIQIUDANBAISHANG,DAOZHIJIQIUDANBAIJIEGOUFASHENGGAIBIANBINGQIESHIJIXIANWEI(JIQIUDANBAIFADONGJI)FASHENGXIANGDUIHUADONG。ZHEISHUYIYIWANJIDEJIQIUDANBAIFADONGJIDECHIXUHUADONG,SHIJIROUCHIXUSHOUSUO,ZHIDAOGAILIZILIKAIJIQIUDANBAI。

皇冠即时比分SHENJING—JIJIETOUDECHUANDIGUOCHENG

皇冠即时比分SHENJING—JIJIETOUDEXINGFENCHUANDISHITONGGUOSHENJINGDIZHIHEDIANBIANHUALIANGGEGUOCHENGLAIWANCHENGDE。JIDANGCHONGDONGCHUANZHIZHOUTUMOSHAOSHI,JIETOUQIANMOYINQUJIHUAERYINQIMOSHANGDEGAITONGDAOKAIFANG,XIBAOJIANYEZHONGDEYIBUFENGAIDEERJIAZHENGLIZIYIRUMONEI。CUSHINANGPAOYUQIANMOJIECHU、RONGHE,RANHOUSHIFANGCHUAch。AchKUOSANDAOZHONGJIMO,BINGYUGAICHUDESHOUTIJIEHE,XINGCHENGAch—SHOUTIFUHEWU.TASHIZHONGBANMOTONGSHIDUISUOYOUXIAOLIZI(BAOKUONALIZI、JIALIZI、LVLIZIDENG,DANYINALIZIWEIZHU)DETONGTOUXINGDOUZENGJIA,NALIZITOURUKUAIERDUO,JIALIZITOUCHUMANERSHAO,YUSHIZHONGBANMOCHANSHENGJUBUQUJIHUA,ZHEIYIDIANBIANHUACHENGWEIZHONGBANDIANWEI。DANGZHONGBANDIANWEIDADAOYIDINGYUZHISHI,KESHIZHONGBANMOLINJINDEJIMOCHANSHENGKEKUOBUDEFENGDIANWEI,YANZHEJIMOCHUANBU,TONGGUOXINGFEN—SHOUSUOOULIANDAOZHIJIROUSHOUSUO。Ca2+YUJIGAIDANBAIJIECONGERCHUXIANJIROUSHOUSUO。

皇冠即时比分LINGWAI,ZHONGBANMOSHANGDEDANJIANZHIMEINENGSHIAchXUNSUSHUIJIEPOHUAI。YINCI,YUNDONGSHENJINGMOSHAOFASHENGYICIDONGZUODIANWEI,ZHINENGYINQIYICIJIXIBAOXINGFEN,CHANSHENGYICISHOUSUO。MOUXIEYAOWURUXINSIDEMING、DUBIANDOUJIANDENG,KEYUDANJIANZHIMEIJIEHE,SHIQISHIQUHUOXING,BUNENGSHUIJIEAch,HUOSHUIJIEDEHENMAN。YIZHIDONGZUODIANWEICHIXUSHIJIANYANZHANG,CHANGYINQIJIROUJINGLUAN。LINGYIXIEYAOWURUJIANDUDENG,NENGYUAchJINGZHENGZHONGBANMOSHANGSHOUTI,ZUDUANAchDEZUOYONG,CONGERYINGXIANGSHENJING—JIJIETOUDEXINGFENCHUANDI,SHIJIROUSONGCHI。WAIKESHOUSHUSHI,KEYINGYONGJIANDULEIYAOWUZUOWEIJIROUSONGCHIJI。

SHENJING—GUGEJIDEXINGFENOULIAN、CHUANDI

皇冠即时比分DANGSHENJINGCHONGDONGCHUANDAOJIXIBAOSHI,CHONGDONGYINQIZHOUTUMOSHAOQUJIHUA,DIANYAMENKONGSHIGAILIZITONGDAOKAIFANG,GAILIZINEILIUYINQINANGPAOYIDONGYIZHIPAIFANG,JIANGQINEIDEYIXIANDANJIANSHIFANGRUSHENJING—JIROUJIETOUJIANXINEI,YIXIANDANJIANYUCUNZAIYUJIXIBAOMOSHANGDEYIXIANDANJIANSHOUTIJIEHE,YINQIZHONGBANMOSHANGDETESHUTONGDAODANBAIZHIKAIFANG,NALIZIDENEILIUHEJIALIZIDEWAILIUSHIJIXIBAOCHANSHENGDONGZUODIANWEI,BINGJIANGQIXUNSUKUOBUDAOZHENGGEXIBAOMO,YUSHIZHENGGEJIXIBAOBIANJINRUXINGFENZHUANGTAI。JIXIBAODEXINGFENBINGBUDENGYUXIBAOSHOUSUO,ZHEIZHONGJIANHAIXUYAOYIGEGUOCHENG。ZHEIGEBAJIXIBAODEDIANXINGFENYUJIXIBAOJIXIESHOUSUOXIANJIEQILAIDEZHONGJIEGUOCHENG,CHENGWEIXINGFENSHOUSUOOULIAN。JUTIDEOULIANGUOCHENGSHI:SHOUXIAN,XIBAOZHIMODEDONGZUODIANWEIKEZHIJIECHUANBIANYUQIXIANGYANXUDEHENGGUANXITONGDEXIBAOMO。HENGGUANDEDONGZUODIANWEIKEZAISANLIANGUANJIEGOUCHUBAXINGFENXINXICHUANDIJIZONGGUANZHONGCHI,SHIZONGGUANMODUIGAILIZIDETONGTOUXINGZENGDA,ZHUCUNYUCHINEIDECa2+BIANHUISHUNQITIDUKUOSANDAOBAOJIANGZHONG,SHIBAOJIANGCa2+NONGDUSHENGGAO,Ca2+YUJIGAIDANBAIJIEHE,CONGERCHUXIANJIROUSHOUSUO。

皇冠即时比分DANGSHENJINGCHONGDONGTINGZHISHI,JIMOJIHENGGUANDIANWEIHUIFU,ZHONGCHIMODUICa2+DETONGTOUXINGJIANGDI,YOUYUCa2+BENGDEZUOYONG,Ca2+HUIDAOZHONGCHI,SHIJIJIANGNEICa2+JIANGDI,Ca2+YUJIGAIDANBAIFENLI,CONGERCHUXIANJIROUSHUZHANG。

SHUZHANGJIROU

皇冠即时比分ZAIYIDUANJINZHANGDEGAIYOUDAOSHOUSUOHOU,GAIBENGKEYISHIJIROUSHUZHANG。GAIBENGSHIZAIJIZHIWANGMOZHONGFAXIANDE,ZAIYOUXIEJIZHIWANGZHONG,TADEHANLIANGFEICHANGDUO,YUEZHANDANBAIZHIZONGSHUDE90%。TONGGUOATPTIGONGNENGLIANG,GAIBENGKEJIANGGAILIZIBENGHUIJIZHIWANGZHONG,CONGERJIANGDIJIDONGDANBAIHEJIQIUDANBAIZHOUWEIDEGAILIZINONGDU,SHIJIROUDEYISHUZHANG。GAILIZIYEBEIDANGZUOXINHAOFENZICUNZAIYUQITAXIBAOZHONG,BINGQIE,LEISIDE”BENG”YEZAIQITADABUFENXIBAOMOZHONGFAXIAN。GAIBENGBUTINGDIGONGZUO,CONGERSHIXIBAOZHINEIDEGAILIZINONGDUJIANGDAOYIGEHENDIDESHUIPING。ZHEIYANG,YIDANZAIYOUXINHAOCHUANRU,XIBAOYOUKEJIANGDALIANGDEGAILIZISHIFANGDAOXIBAOZHIZHONG,YINQIJIROUSHOUSUO。

5CHAOZAIXIANXIANG

GEZHONGYUANYINYINQIDEXIBAONEIGAINONGDUMINGXIANZENGDUOBINGDAOZHIXIBAOJIEGOUSUNSHANGHEGONGNENGDAIXIEZHANGAIDEXIANXIANGCHENGWEIGAICHAOZAI( calcium overload )。 XIBAONEIGAICHAOZAIDEFASHENGJIZHI:

皇冠即时比分1 . Na+ /Ca2+ JIAOHUANYICHANG SHENGLITIAOJIANXIA, Na+/Ca2+ JIAOHUANDANBAIZHUANYUNFANGXIANGSHIJIANGXIBAONEI Ca2+ YUNCHUXIBAO,YUXIBAOMOGAIBENGGONGTONGWEICHIXINJIXIBAOJINGXIZHUANGTAIDEDIGAINONGDU。 Na+ /Ca2+ JIAOHUANDANBAIYI 3 GE Na+ JIAOHUAN 1 GE Ca2+ DEBILIDUIXIBAONEIWAI Na+ 、 Ca2+ JINXINGSHUANGXIANGZHUANYUN。 Na+ /Ca2+ JIAOHUANDANBAIDEHUOXINGZHUYAOSHOUKUAMO Na+ NONGDUDEDIAOJIE,CIWAIHAISHOU Ca2+ 、 ATP 、 Mg2+ 、H+ NONGDUDEYINGXIANG。YIYOUDALIANGDEZILIAOZHENGSHI, Na+/Ca2+ JIAOHUANDANBAISHIQUEXUE- ZAIGUANZHUSUNSHANGHEGAICHAOZAISHIGAILIZIJINRUXIBAODEZHUYAOTUJING。

(1) XIBAONEIGAO Na+ DUI Na+ /Ca2+ JIAOHUANDANBAIDEZHIJIEJIHUOZUOYONG:QUEXUESHIXIBAONEI ATP HANLIANGJIANSHAO,NABENGHUOXINGJIANGDI,ZAOCHENGXIBAONEINAHANLIANGZENGGAO。ZAIGUANZHUSHIQUEXUEDEXIBAOZHONGXINHUODEYANGJIYINGYANGWUZHIGONGYING,XIBAONEIGAO Na+ CHUJIHUONAJIABENGWAI,HAIXUNSUJIHUO Na+ /Ca2+ JIAOHUANDANBAI,YIJIASU Na+ XIANGXIBAOWAIZHUANYUN,TONGSHIJIANGDALIANG Ca2+ ZHUANRUXIBAONEI,ZAOCHENGXIBAONEI Ca2+ CHAOZAI。

(2) XIBAONEIGAO H+ DUI Na+ /Ca2+ JIAOHUANDANBAIDEJIANJIEJIHUOZUOYONG:ZHIMO Na+ /H+ JIAOHUANDANBAIZHUYAOSHOUXIBAONEI H+ NONGDUDEBIANHUA,YI 1:1 DEBILIJIANGXIBAONEIDE H+ PAICHUBAOWAI,ERJIANG Na+ SHERUXIBAO,ZHEISHIWEICHIXIBAONEI PH WENDINGDEZHONGYAOJIZHI。QUEXUEQUEYANGQI,YOUYUXIBAODEWUYANGDAIXIEZENGQIANGSHI H+ SHENGCHENGZENGJIA,ZUZHIJIANYEHEXIBAONEIYE PH MINGXIANJIANGDI。ZAIGUANZHUSHIZUZHIJIANYE H+ NONGDUXUNSUXIAJIANG,ERXIBAONEI H+ NONGDUHENGAO,XINGCHENGKUAMO H+ NONGDUTIDU。XIBAOMOLIANGCE H+ NONGDUCHAKEJIHUOXINJI Na+ /H+ JIAOHUANDANBAI,CUJINXIBAONEI H+ PAICHU,ERSHIXIBAOWAI Na+ NEILIU。RUGUONEILIUDE Na+ BUNENGBEINABENGCHONGFENPAICHU,XIBAONEIGAO Na+ KEJIFAXINGJIHUO Na+ /Ca2+ JIAOHUANDANBAI,CUJIN Ca2+ NEILIU,JIAZHONGXIBAOGAICHAOZAI。

(3) DANBAIJIMEI C ( PKC )HUOHUADUI Na+/Ca2+ JIAOHUANDANBAIDEJIANJIEJIHUOZUOYONG:SHENGLITIAOJIANXIA,XINGONGNENGZHUYAOSHOU β SHENSHANGXIANSUNENGSHOUTIDIAOJIE, α1 SHENSHANGXIANSUNENGSHOUTIDEDIAOJIEZUOYONGJIAOXIAO。DANQUEXUE – ZAIGUANZHUSUNSHANGSHI,NEIYUANXINGERCHAFENANSHIFANGZENGJIA, α 1 SHENSHANGXIANSUNENGSHOUTIDEDIAOJIEXIANGDUIQIZHONGYAOZUOYONG。 α1 SHENSHANGXIANSUNENGSHOUTIJIHUO G DANBAI – LINZHIMEI C ( PLC )JIEDAODEXIBAOXINHAOZHUANDAOTONGLU,CUJINLINZHIXIANJICHUNFENJIE,SHENGCHENGSANLINSUANJICHUN( IP3 )HEGANYOUERZHI( DG ),CUJINXIBAONEI Ca2+ DESHIFANG; DG JINGJIHUO PKC CUJIN Na+ /H+ JIAOHUAN,JINERCUJIN Na+/Ca2+ JIAOHUAN,SHIBAOJIANG Ca2+ NONGDUZENGJIA。

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